Nice tips by Bill Griffith about making comics (though lots of them are useful to any kind of artist), from ideas, technique and art to distribution and publishing. Read all of them here (via McCloud) .
31) Aside from trying to communicate, don`t think of your readers when you create your comics. Please yourself and a few friends. Then hope for the best.
2) It can take years to find something to write about.
25) When starting out, try to get in print as quickly as possible. Seeing your work in print is tremendously educational. All your mistakes leap out. Educational, but painful. If you do strips (as opposed to longer stories) try your weekly papers first. Self-publish. Any way to get into print is good, including the web.